Comalcalco is a city located in Comalcalco Municipality about 45 miles (60 km) northwest of Villahermosa in the Mexican state of Tabasco. Near the city is the Pre-Columbian Maya archaeological site of Comalcalco. The literal English translation of "Comalcalco" is "In the house of the comals". A comal is a pan used to prepare food.

The present-day city of Comalcalco reported a 2020 census population of 43,035 inhabitants, while the municipality of which it serves as municipal seat had a population of 214,877. The city is the third most populous community in the state of Tabasco, behind Villahermosa and Cárdenas. The municipality, which has an area of 723.19 km² (279.225 sq mi), includes many smaller outlying communities, the largest of which are Tecolutilla, Chichicapa, Cupilco, Villa Aldama, Gobernadores, Tomas Garrido and Miguel Hidalgo.

The site of Comalcalco, whose coordinates are 18°16′N 93°10′W, is notable for two characteristics. First, it is the westernmost known Maya settlement. Second, and due to a dearth of locally available limestone (the primary material used in architectural construction), the city's buildings were made from fired-clay bricks held together with mortar made from oyster shells. The use of bricks at Comalcalco was unique among Maya sites, and many of them are decorated with iconography and/or glyphs. Important architectural features include the northern plaza and two pyramids, the Gran Acropolis and the Acropolis Este.

Comalcalco has fertile soil. Large amounts of tropical products are grown. Corn and beans and vegetables are also cultivated. Cocoa is the largest harvest in Comalcalco. Comalcalco produces 20% of the cocoa harvested in the state of Tabasco. Also coconut, pepper, avocado and some tropical fruits are important in some zones. Livestock raising, even though it is not widely practiced, is of high quality, most ranchers have their farms just sideout of Comalcalco, away from urban development.

Comalcalco produces 5% of the total extracted petroleum in the state of Tabasco.

In 1820, the river Mezcalapa was drying up, and many of the families made residence in the middle of the river on an island. The Government of the State of Tabasco; consisting of Juan Mariano Sale, Antonio Solana and Fausto Gordillo, and all members of the congress; established a town in October, and named it San Isidro de Comalcalco. The decree was published by Mr. Marcelino Margalli, governor of the state and Jose Mariano Troncoso, who was secretary of the state. The town is located in the Comalcalco municipalities, and on November 14 of 1834 the first local government was created.

• Link to tables of population data from Census of 2005 at the Wayback Machine (archived March 16, 2007) INEGI: Instituto Nacional de Estadística, Geografía e Informática
• Tabasco at the Wayback Machine (archived January 4, 2014) Enciclopedia de los Municipios de México

• Official Website Ayuntamiento de Comalcalco
• Ayuntamiento de Comalcalco. "Descripción Actual del Municipio". Archived from the original on October 13, 2007. Retrieved 2015-09-24.
• Ayuntamiento de Comalcalco. "Fundación de la Ciudad de Comalcalco". Archived from the original on October 13, 2007. Retrieved 2015-09-24.

18°16′48.29″N 93°12′6.31″W / 18.2800806°N 93.2017528°W / 18.2800806; -93.2017528